--- title: What You Need to Know About Spinal Cord Regeneration description: Spinal cord nerve regeneration is an area of research that has made significant advances over the past several decades, particularly concerning spinal cord regeneration stem cells. image: https://www.spinalcord.com/hubfs/spinal-cord-research-blog2.jpeg --- [![spinalcord logo desktop](https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png) ![spinalcord logo mobile](https://www.spinalcord.com/hubfs/Logos/spinal-cord-white_png.png) ](https://www.spinalcord.com/) MENU ** ![spinal cord logo slide out mobile](https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png) ** [![Dale Swope](https://www.spinalcord.com/hs-fs/hubfs/dale-img-min.jpg?width=100&name=dale-img-min.jpg) The Purpose Behind Spinalcord.com ** Play Dale Swope's Story ](https://www.youtube.com/watch?v=C1kPXDw_CQU) [For Advice Call: (877) 336-7192 ](tel:8773367192) ![Spinalcord Logo](https://www.spinalcord.com/hubfs/Logos/spinal-cord-logo-icon-svg.svg) - 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[Community](https://www.spinalcord.com/spinal-cord-injury-community) - [Trusted Organizations](https://www.spinalcord.com/trusted-by-the-spinal-cord-injury-community) - [Events Calendar](https://www.spinalcord.com/events) - [Podcast](https://www.spinalcord.com/sci-life-uncovered/episode-1) - Recognition - [Best of Awards](https://www.spinalcord.com/best-of-awards) - [Trusted By Designation](https://www.spinalcord.com/trusted-by-the-spinal-cord-injury-community) - [** ](tel:8773367192) - [** ](https://www.spinalcord.com/blog/what-you-need-to-know-about-spinal-cord-regeneration#) - [** **(877) 336-7192** ](tel:8773367192) - [** **Contact Us** ](https://www.spinalcord.com/contact-us) # What You Need to Know About Spinal Cord Regeneration Author: [Spinal Cord Team](https://www.spinalcord.com/meet-our-authors) Publish Date: December 08, 2020 Spinal cord regeneration is the goal of every [spinal cord injury](https://www.spinalcord.com/spinal-cord-injury) (SCI) survivor. The idea that your spinal cord, or the [spinal cord](https://www.spinalcord.com/what-is-the-spinal-cord) of someone you love, would be able to regenerate after a traumatic injury may seem nearly impossible if you were to believe long-accepted “knowledge” about spinal cord injury regeneration research. Although there currently is no cure for spinal cord injuries, the good news is that new research on spinal cord nerve regeneration is always taking place in the U.S. and around the world. This means that long-accepted ideologies of these traumatic injuries are continually challenged, and knowledge of these injuries is changing and growing as researchers seek to find a cure. ## **There Are Four Key Principles of Spinal Cord Regeneration** According to [neuro-regeneration and spinal cord injury research at Mayo Clinic](https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/neuroregeneration), there are four key components to spinal cord repair: - Protecting surviving nerve cells from further damage - Replacing damaged nerve cells - Stimulating the regrowth of axons and targeting their connections appropriately - Retraining neural circuits to restore body functions. The institution reports that its researchers also have completed animal research studies that show promise for the future regeneration of spinal cord nerve connections. The research involved the implantation of a biodegradable polymer scaffold that is loaded with Schwann cells from the peripheral nervous system along with neurotrophins. ## **Prevailing Theories of CNS Regeneration May Not Be True** As new research on the central nervous system (CNS) and spinal cord continue to take place, they show that something that was once accepted as being impossible to change may not necessarily be the case. When it comes to the topic of central nervous system regeneration (and spinal cord regeneration as a component of it) in neuroscience, [three theories](https://www.ncbi.nlm.nih.gov/pubmed/24816452) have somehow become accepted as commonplace knowledge to explain why the adult central nervous system can’t regenerate: 1. **Nogo **—a molecule found in the protective sheathing around the nerve fibers in the central nervous system (myelin), blocks the growth of axons. 2. **[Glial scars](https://www.christopherreeve.org/blog/research-news/glia-scar-not-the-villain-in-spinal-cord-regeneration) **— a type of tissue that forms after an injury to the central nervous system in a process known as astrogliosis (when astrocytes rush to the area of injury and surround it to create a protective barrier) — prevent axon growth. 3. **Chondroitin sulfate proteoglycans** (CSPGs)— prevent the growth of axons. However, some researchers have reported the regeneration of spinal tracts in animal SCI research studies in some circumstances despite the presence of Nogo-expressing tissue and glial scars. [One study](https://www.ncbi.nlm.nih.gov/pubmed/27027288) even showed that preventing astrocytic glial scar formation *reduced* stimulated axon regrowth, meaning that stopping the creation of the scar tissue has an adverse effect on CNS and spinal cord regeneration. While, in some ways, spinal cord regeneration research may feel like the margarine versus butter argument — which, for years, researchers continually flip-flopped about which was better (or worse) for your health. But, the good news is that by changing preconceived notions about spinal cord regeneration, it opens new doors to future research in those areas that had long been mostly abandoned. ## **Spinal Cord Regeneration Stem Cells Show Promise** Over the past several years, we have shared a number of articles on the topic of stem cells in [spinal cord injury research](https://www.spinalcord.com/blog/topic/research). Some studies have even shown some spinal cord injury survivors recovering some [functional movement](https://www.spinalcord.com/blog/first-paralyzed-man-treated-with-stem-cells-has-regained-movement) as a result of stem cell injections. Some other studies focus on removing barriers that stand in the way of achieving spinal cord regeneration. One animal [research study](https://www.spinalcord.com/blog/how-the-use-of-smell-cells-may-promote-spinal-cord-nerve-regeneration) used self-regenerating stem cells from the olfactory system to secrete a specific enzyme (chondroitinase ABC, or ChABC) to help promote axonal regeneration. Most recently, we [wrote an article](https://www.spinalcord.com/blog/spinal-cord-injury-research-advances-with-new-stem-cells) on some new advances in neural stem cell (NSC) research that “could have clinical applications in spinal cord injury and disorder treatments.” The study involved grafting immature cultured human pluripotent stem cells (hPSCs) into the spinal cords of rodents with SCIs so they would morph into different types of stem cells throughout the spinal cord. The grafts resulted in promoting some corticospinal axon regeneration and supported functional recovery in the rats. ## **The Future of Spinal Cord Regeneration** Although it is likely frustrating to hear or read studies about incremental changes or advances in spinal cord research, it’s important to know that researchers are dedicating their professional lives to finding a cure. The hope is that some of these animal studies will be successful enough to move on to a human trial phase to help regenerate spinal cord nerves and spinal cord tissue. While we wait for these incredible advances, it’s important to remember that you and your family are not alone. There is an entire [community of spinal cord injury survivors and loved ones](https://www.spinalcord.com/spinal-cord-injury-community) who are here to support, learn, and help each other grow. To learn more about spinal cord injuries, be sure to check out our complimentary resource by clicking on the link below. [![understanding-spinal-cord-injury-guide](https://no-cache.hubspot.com/cta/default/575040/096a7074-9474-4c57-8948-3c9b97281302.png)](https://cta-redirect.hubspot.com/cta/redirect/575040/096a7074-9474-4c57-8948-3c9b97281302)  **Topics:** Spinal Cord Injury, Research, Treatment ### Stay Updated on Advancements On Traumatic Brain & Spinal Cord Injuries About the Author #### Spinal Cord Team The authors of Spinalcord.com are made up of attorneys, those in the medical field, and survivors of spinal cord injuries or traumatic brain injuries. Learn more about our team of authors including a brief biography that explains how they impact the SCI and TBI community. [Learn More About the Author](https://www.spinalcord.com/meet-our-authors) **Leave a Comment** [![New Call-to-action](https://no-cache.hubspot.com/cta/default/575040/dc8bc979-ba55-463a-9400-f92cbdebcb1a.png)](https://cta-redirect.hubspot.com/cta/redirect/575040/dc8bc979-ba55-463a-9400-f92cbdebcb1a) true ### Spinal Cord Injury - [Types of Spinal Cord Injuries](https://www.spinalcord.com/types-of-spinal-cord-injuries) - [Secondary Complications](https://www.spinalcord.com/secondary-complications-after-sci-spinal-cord-injury) - [Causes](https://www.spinalcord.com/signs-symptoms-of-spinal-cord-injuries) - [Symptoms](https://www.spinalcord.com/types-of-spinal-cord-injuries) - [Prognosis](https://www.spinalcord.com/prognosis-of-spinal-cord-injuries) - [Legal Help](https://www.spinalcord.com/spinal-cord-injury-legal-help-get-a-lawyer) ### Brain Injury - [Types of Brain Injuries](https://www.spinalcord.com/types-of-traumatic-brain-injury) - [Causes](https://www.spinalcord.com/causes-of-traumatic-and-acquired-brain-injuries) - [Symptoms](https://www.spinalcord.com/traumatic-brain-injury-tbi-symptoms) - [Prognosis](https://www.spinalcord.com/brain-injury-prognosis-for-tbi-abi) - [Legal Help](https://www.spinalcord.com/brain-injury-legal-help-get-a-lawyer) ### Finding Treatment - [Physician Directory](https://www.spinalcord.com/brain-and-spinal-cord-injury-physician-directory) - [Rehabilitation Directory](https://www.spinalcord.com/spinal-cord-injury-hospitals-rehabilitation-directory) - [Technology Advancements](https://www.spinalcord.com/sci-technology-advancements) - [Prevention](https://www.spinalcord.com/spinal-cord-injury-prevention) ### Legal Options - [Spinal Cord Injury Lawyer](https://www.spinalcord.com/spinal-cord-injury-lawyer) - [Brain Injury Lawyer](https://www.spinalcord.com/brain-injury-lawyer) - [Types of Personal Injury Claims](https://www.spinalcord.com/types-of-personal-injury-claims) - [Where To Start](https://www.spinalcord.com/brain-spinal-cord-injury-lawyer-where-to-start) - [Local Assistance](https://www.spinalcord.com/florida-personal-injury-claims) #### [About Us](https://www.spinalcord.com/about-us) Spinal cord injuries are traumatic for patients and their families. They cause disruptive changes to every aspect of your life and there is a lot of new information to navigate and understand. Our experts have collected everything in one place to help you learn more about your injury, locate doctors and treatment centers, find financial support, and get assistance navigating your next move. [Learn More About SpinalCord.com →](https://www.spinalcord.com/about-us) ## [Contact Us](https://www.spinalcord.com/contact-us) ![logo-footer-spinal-cord.png](https://www.spinalcord.com/hs-fs/hubfs/img/logo-footer-spinal-cord.png?width=249&name=logo-footer-spinal-cord.png "logo-footer-spinal-cord.png") **  [877-336-7192](tel:8773367192) ** [support@spinalcord.com](mailto:support@spinalcord.com) [**](https://www.facebook.com/spinalcordcom) [**](https://www.linkedin.com/company/spinalcord-com/) [**](https://twitter.com/SpinalCordCom) [**](https://www.youtube.com/channel/UCAbz2AC18acXQkpMNPeDIqg) Copyright 2026 | All Rights Reserved. [Spinal Cord, Inc.](https://www.spinalcord.com) Sponsored by [Tampa personal injury lawyers](https://www.swoperodante.com/tampa-personal-injury-lawyer/) at Swope, Rodante P.A. a Florida law firm located at 1234 E 5th Ave, Tampa, FL 33605. The information provided by SpinalCord.com is not a substitute for professional medical advice, diagnosis, or treatment, see [ Disclaimer Policy.](https://www.spinalcord.com/disclaimer) [**](https://www.spinalcord.com/blog/what-you-need-to-know-about-spinal-cord-regeneration#) [**](https://www.spinalcord.com/blog/what-you-need-to-know-about-spinal-cord-regeneration#) ```json { "@context" : "https://schema.org", "@type" : "WebSite", "name" : "Spinal Cord, Inc.", "potentialAction" : { "@type" : "SearchAction", "query-input" : "required name=search_query", "target" : "https://www.spinalcord.com/search?q={search_query}" }, "url" : "https://www.spinalcord.com/" } ``` ```json { "@context" : "https://schema.org", "@type" : "Organization", "contactPoint" : [ { "@type" : "ContactPoint", "contactType" : "customer service", "telephone" : "+1-877-336-7192" } ], "legalName" : "Spinal Cord, Inc.", "logo" : "https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png", "sameAs" : [ "https://www.facebook.com/spinalcordcom", "https://twitter.com/SpinalCordCom", "https://www.youtube.com/channel/UCAbz2AC18acXQkpMNPeDIqg", "http://www.linkedin.com/company/spinalcord-com" ], "url" : "https://www.spinalcord.com/" } ``` ```json { "@context" : "http://schema.org", "@type" : "Article", "articleBody" : "The spinal cord is a vital part of the human body. As the vehicle responsible for carrying messages from the brain to the rest of the body and back again, even the smallest interference can be detrimental. Following a traumatic spinal cord injury, this bundle of nerves can become bruised, also known as a contusion. Because of the nature of the nervous system, any interference can constitute a serious spinal contusion, but these facts will help you dissect all of the information from the medical professionals.

\n\n

What Is a Spinal Contusion?

\n\"Signs-of-a-spinal-contusion-title-image\"\n

Much like any other bruise, a contusion can cause bleeding from local blood vessels and inflammation which, rather unlike bruises on other parts of the body, can have serious negative impacts on the spinal cord itself. Because the “blood must clot to stop the bleeding”a bruise results from contusions also increase cardiovascular risks.

\n

For example, the swelling a contusion can cause will often disrupt nerve impulses that travel from the brain to the body through the spinal cord, and the severity of this will depend upon the level of injury. Unlike a concussion, a contusion would not cause unconsciousness or a ‘blackout’, but instead cause the patient to feel a numbness or tingling in the extremities.

\n

A contusion can cause spinal compression, which happens when there is pressure on the spinal cord. This can go on to cause an array of physical symptoms such as loss of sensation in the feet, inability to use the hands and loss of sexual ability. It must be noted that not all contusions cause spinal compression, and not all spinal compression is caused by a contusion, although they do often connect this way.

\n

Warning Signs of a Serious Spinal Contusion to Watch For

\n

Firstly, doctors will try and establish what area or limb the injury has affected. Spinal contusions most often “affect the upper extremities bilaterally and also sometimes involve the lower extremities,” according to Dr. Wong, an orthopedic physician.

\n

Symptoms include “numbness, tingling, [or] electric shock-like sensations and burning in the extremities,” (American Association of Neurological Surgeons, 2016). Generally falling into the category of “spinal trauma” there are many symptoms which are similar to other forms of spinal trauma and spinal cord injury. Below are some symptoms of spinal trauma:

\n\n

Unfortunately, it is sometimes challenging to identify which symptoms are due to a spinal contusion, and which ones are the result of a spinal cord injury directly. It can sometimes require a few days or weeks for the body to recover from spinal trauma and reveal if any permanent damage is left from the accident that caused the SCI.

\n

Understanding what a contusion is, and how it can come into play following a spinal cord injury is important in order to clearly appreciate your injury, understand your diagnoses, and work toward treatment and a prognosis. Doctors can sometimes use jargon that’s difficult to understand, so the more you can educate yourself about your condition, the more control you can have in your recovery and treatment.

\n

If you still have questions about the details of the spinal cord and how it may be affected from your injury, please contact us or download our guide to understanding a spinal cord injury.", "author" : { "@type" : "Person", "name" : "Spinalcord.com Team" }, "datePublished" : "2020-12-03", "image" : "https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion", "name" : "Warning Signs of a Serious Spinal Contusion", "url" : "https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion" } ``` ```json { "@context":"https://schema.org", "@graph":[{"@type":"WebSite", "@id":"https://spinalcord.com/#website", "url":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion", "name":"Spinal Cord Inc", "description":"The spinal cord is a vital part of the human body. As the vehicle responsible for carrying messages from the brain to the rest of the body and back again, even the smallest interference can be detrimental. Following a traumatic spinal cord injury, this bundle of nerves can become bruised, also known as a contusion. Because of the nature of the nervous system, any interference can constitute a serious spinal contusion, but these facts will help you dissect all of the information from the medical professionals.", "inLanguage":"en-US"}, { "@type":"ImageObject", "@id":"Spinalcord Logo", "inLanguage":"en-US", "url":"https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png", "width":327,"height":300, "caption":"spinal contusion"}, { "@type":"WebPage","@id":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/#webpage", "url":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion", "name":"Warning Signs of a Serious Spinal Contusion", "isPartOf":{"@id":"https://spinalcord.com/#website"}, "primaryImageOfPage":{"@id":"www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/#primaryimage"}, "datePublished":"2020-12-03T18:30:35+00:00","dateModified":"2020-12-03T18:30:35+00:00", "author":{"@id":"https://www.spinalcord.com/meet-our-authors"}, "description":"The spinal cord is a vital part of the human body. As the vehicle responsible for carrying messages from the brain to the rest of the body and back again, even the smallest interference can be detrimental. Following a traumatic spinal cord injury, this bundle of nerves can become bruised, also known as a contusion. Because of the nature of the nervous system, any interference can constitute a serious spinal contusion, but these facts will help you dissect all of the information from the medical professionals. What Is a Spinal Contusion? Signs-of-a-spinal-contusion-title-image Much like any other bruise, a contusion can cause bleeding from local blood vessels and inflammation which, rather unlike bruises on other parts of the body, can have serious negative impacts on the spinal cord itself. Because the “blood must clot to stop the bleeding”a bruise results from contusions also increase cardiovascular risks. For example, the swelling a contusion can cause will often disrupt nerve impulses that travel from the brain to the body through the spinal cord, and the severity of this will depend upon the level of injury. Unlike a concussion, a contusion would not cause unconsciousness or a ‘blackout’, but instead cause the patient to feel a numbness or tingling in the extremities. A contusion can cause spinal compression, which happens when there is pressure on the spinal cord. This can go on to cause an array of physical symptoms such as loss of sensation in the feet, inability to use the hands and loss of sexual ability. It must be noted that not all contusions cause spinal compression, and not all spinal compression is caused by a contusion, although they do often connect this way. Warning Signs of a Serious Spinal Contusion to Watch For Firstly, doctors will try and establish what area or limb the injury has affected. Spinal contusions most often “affect the upper extremities bilaterally and also sometimes involve the lower extremities,” according to Dr. Wong, an orthopedic physician. Symptoms include “numbness, tingling, [or] electric shock-like sensations and burning in the extremities,” (American Association of Neurological Surgeons, 2016). Generally falling into the category of “spinal trauma” there are many symptoms which are similar to other forms of spinal trauma and spinal cord injury. Below are some symptoms of spinal trauma: Spinal shock — or the loss of feeling or movement below site of injury (Columbia University Medical Centre, 2016) that can last between hours and weeks Loss of bladder or bowel function Difficulty breathing Muscle spasticity Difficulty understanding speech Problems with attention Memory challenges Heart rate and blood pressure problems Unfortunately, it is sometimes challenging to identify which symptoms are due to a spinal contusion, and which ones are the result of a spinal cord injury directly. It can sometimes require a few days or weeks for the body to recover from spinal trauma and reveal if any permanent damage is left from the accident that caused the SCI. Understanding what a contusion is, and how it can come into play following a spinal cord injury is important in order to clearly appreciate your injury, understand your diagnoses, and work toward treatment and a prognosis. Doctors can sometimes use jargon that’s difficult to understand, so the more you can educate yourself about your condition, the more control you can have in your recovery and treatment. If you still have questions about the details of the spinal cord and how it may be affected from your injury, please contact us or download our guide to understanding a spinal cord injury.", "breadcrumb":{"@id":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/#breadcrumb"}, "inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion"]}]}, { "@type":"BreadcrumbList", "@id":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/#breadcrumb", "itemListElement":[{"@type":"ListItem", "position":1, "item": { "@type":"WebPage", "@id":"https://spinalcord.com/", "url":"https://spinalcord.com/", "name":"Home"}}, {"@type":"ListItem", "position":2, "item":{"@type":"WebPage", "@id":"https://spinalcord.com/blog/", "url":"https://spinalcord.com/blog/", "name":"Articles"}}, {"@type":"ListItem", "position":3, "item":{"@type":"WebPage", "@id":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/", "url":"https://www.spinalcord.com/blog/signs-of-a-serious-spinal-contusion/", "name":"Warning Signs of a Serious Spinal Contusion"}}]}, {"@type":"Person", "@id":"https://www.spinalcord.com/meet-our-authors", "name":"Spinalcord Team", "image":{"@type":"ImageObject", "@id":"https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png", "inLanguage":"en-US", "url":"https://www.spinalcord.com/hubfs/Logos/spinal-cord_png.png", "caption":"Spinalcord Team"}, "description":"The authors at SpinalCord.com come from diverse backgrounds including doctors, attorneys, medical journalist, and survivors of spinal cord injuries or traumatic brain injuries. Each author brings with them different experiences and expertise which when combined provide clinically accurate information which is useful to all individuals in the spinal cord and traumatic brain injury communities. Within the content you will find citations to medical journals, scientific research, as well as national and local resources to provide immediate support to families in need of assistance. Content is reviewed and updated regularly with changes in the clinical guidelines, new resources, and fresh ways to understand the content such as videos and infographics. ." } ]} ```